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Thus, PP might also detect CKD progression effectively. It was suggested that PP might be a superior predictor for coronary heart disease compared with SBP and DBP 20. Pulse pressure (PP), which is easily calculated by subtracting the diastolic blood pressure (DBP) from systolic blood pressure (SBP), is a potential marker for atherosclerotic diseases including cardiovascular disease 16, 17, 18, 19, 20, heart failure 16, 21, and stroke 16. Among them, high blood pressure is one of the most established prognostic factors for CKD progression 6, 7, 8. Some conditions such as high blood pressure 8, 9, 10, hyperglycemia 11, 12, 13, and smoking 14, 15 are thought to be risk factors for CKD progression. Patients with CKD incur tremendous health care costs 6, 7 thus, CKD is a highly prioritized public health issue. CKD also leads to cardiovascular disease or mortality 4, 5. CKD is an important and established risk factor for end-stage renal disease (ESRD) and renal replacement therapy 2, 3. PP might be a potential predictive marker for CKD progression.Ĭhronic kidney disease (CKD) is characterized by renal function decline and/or the presence of albuminuria 1. In conclusion, we found a significant association between PP and CKD progression. PP remained a potential predictive marker, especially for eGFR decline. This trend did not change significantly irrespective of baseline systolic or diastolic blood pressures. Similar results were obtained even after dividing PP into quartiles. A significant increase existed in CKD progression per 10 mmHg of PP elevation, even when adjusted for confounding factors. During a 4.66-year mean follow-up, there were 241 cases of CKD progression (incident rate: 49.
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Cox’s proportional hazard model was used to evaluate the association between PP and progression of CKD. We identified 1042 participants who had CKD (estimated glomerular filtration rate(eGFR) < 60 mL/min/1.73 m 2 or the presence of proteinuria) at baseline. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan.